منابع مشابه
Diffusion changes in the aging human brain.
BACKGROUND AND PURPOSE Quantifying changes in the human brain that occur as part of normal aging may help in the diagnosis of diseases that affect the elderly and that cause structural changes in the brain. We sought to assess diffusion changes that are inherently related to brain structure during aging. METHODS MR scans were obtained from 11 healthy volunteers and 27 patients (ages 26 to 86 ...
متن کاملFactors associated with morphometric brain changes in cognitively normal aging
Objective Cognitive impairment is associated with reductions in brain weight and volume. The factors related to morphometric brain changes in cognitively normal aging remain unknown. We aimed to identify which clinical factors are associated with morphometric brain changes in cognitively normal aging. Methods A cross-sectional study of 414 subjects, ≥50 years old submitted to clinical assessm...
متن کاملQuantitative in vivo measurement of gyrification in the human brain: changes associated with aging.
Clinical observation suggests that the aging process affects gyrification, with the brain appearing more 'atrophic' with increasing age. Empirical studies of tissue type indicate that gray matter volume decreases with age while cerebrospinal fluid increases. Quantitative changes in cortical surface characteristics such as sulcal and gyral shape have not been measured, however, due to difficulti...
متن کاملWidespread splicing changes in human brain development and aging
While splicing differences between tissues, sexes and species are well documented, little is known about the extent and the nature of splicing changes that take place during human or mammalian development and aging. Here, using high-throughput transcriptome sequencing, we have characterized splicing changes that take place during whole human lifespan in two brain regions: prefrontal cortex and ...
متن کاملThe neuropathological changes associated with normal brain aging.
Neurofibrillary tangles and senile plaques are common neuropathological features in both normal brain aging and Alzheimer's disease. In order to examine the patterns of lesion distribution in cerebral aging, we review the clinicopathological analysis of 1144 nondemented cases comparing their neuropathologic features to that reported in cases with mild cognitive impairment and cases with Alzheim...
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ژورنال
عنوان ژورنال: Journal of Neuropathology and Experimental Neurology
سال: 1997
ISSN: 0022-3069
DOI: 10.1097/00005072-199712000-00001